Tridensimilis is a genus of catfishes (order Siluriformes) of the family Trichomycteridae. It includes two species, T. brevis and T. venezuelae. T. brevis is distributed in the Amazon River basin in Brazil, while T. venezuelae is distributed in the Orinoco basin in Venezuela. Both species grow to about 2.5–3.0 centimetres TL. T. brevis lives in the sand of shallow rivers and creeks. It is parasitic, entering the gill chambers of larger catfishes. It is also known for entering, probably by mistake, the urethra of mammals urinating under water.
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