Oscar Guillermo Sanguinetti Giordano (born June 21, 1966 in Montevideo) is a retired football defender and midfielder from Uruguay, who was nicknamed "Topo". Having made his debut on May 5, 1991 against the United States (0-1), he obtained a total number of twenty international caps for his national team, scoring one goal, in the 1990s.
Sanguinetti played for a number of Uruguayan football clubs before joining Gimnasia y Esgrima de La Plata in Argentina where he played 390 games scoring 32 goals between 1991 and 2003.