Nesoryzomys darwini, also known as '''Darwin's Nesoryzomys or Darwin's Galapagos Mouse', is a species of rodent in the genus Nesoryzomysthat lived on Santa Cruz Island in the Galapagos Islands. It was probably nocturnal and inhabited burrows or rock crevices under bushes. Only four specimens exist, collected by Frank Wonder between 12 and 16 January 1929. This extinction may have been caused by competition and disease created by the introduction of nonnative brown and black rats.
The other Nesoryzomysknown from Santa Cruz, Nesoryzomys indefessus, is also extinct there; other species of the genus survive on different islands.
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