Domingo Cullen (1791 21 June 1839) was the governor of province of Santa Fe, Argentina during 1838.
Cullen was born in Tenerife, Canary Islands, but moved to Argentina in the 1820s after establishing commercial activities (linked with fluvial trade) in the area. He met Santa Fe's caudillo Estanislao Lopez when serving as a deputy of the Cabildo of Montevideo. After being involved in activism related to the independence of Uruguay and the resistance against Brazil (see Argentina-Brazil War), he returned to Santa Fe, settled in a ranch, and married Joaquina Rodriguez del Fresno, the young widow of Pedro Aldao and sister-in-law of Lopez. In 1828 he became a counselor of Lopez, and his Minister of Government in 1833.
At the time of Lopez's death on 15 June 1838, Cullen was in Buenos Aires as representative of Santa Fe, trying to find a peaceful solution to the ongoing French blockade of the port (caused by a law of 1821 that obligated resident foreign citizens of the province of Buenos Aires to serve in conscription).